Time magazine ran a cover story in February 2004 on cellular inflammation and another story on inflammation in April 2018. The New York Times had an article in the personal health section on December 23, 2019 titled “Tackling Inflammation to Fight Age-Related Ailments”. These articles reported that specialists in the biology of ageing, researchers and […]
Glutathione (GSH) is synthesized in the cytoplasm in virtually all cells from its constituent amino acids by two sequential ATP-requiring enzyme catalyzed reactions (see figure below) [1]. : The first reaction is rate limiting and is catalysed by glutamate cysteineligase (GCL, EC 6.3.2.2; formerly γ-glutamylcysteine synthetase). GCL is composed of a heavy catalytic subunit (GCLC, […]
By far the best, if not the only way to increase your cellular glutathione (GSH) is to take the glutathione precursor, gamma-glutamylcysteine (Glyteine). GSH is produced in two steps in every cell of your body, the first makes gamma-glutamylcysteine (a dipeptide of glutamate and cysteine) and the second adds a glycine to the gamma-glutamylcysteine to […]
One of the impediments to knowing ones GSH status is the lack of standardized analytical methods for determining GSH is blood, plasma, tissue and cellular material. Unlike most other biochemical blood markers (e.g. cholesterol or glucose) GSH analysis it is not part of the regular battery of tests performed when a blood sample is taken. […]
Free radicals are uncharged molecules with unpaired electrons in their outermost valence shell. Free radicals are by-products of chemical processes such as oxidation and all oxidation processes occur via a free radical mechanism. The body’s ability to release energy from the food we eat and the oxygen we breathe occurs by an oxidation process called […]
Maintaining cellular glutathione levels is essential to good health. Unfortunately, for most diseases and disorders and during ageing itself, our bodies lose the capacity to produce glutathione at homeostatic levels that are high enough to fight off the ravages of oxidative stress. Glyteine is the immediate precursor to glutathione and is the only nutrient with […]
Glutathione is often termed the “master antioxidant”. It is produced and used in every cell in your body. In fact, every living organism from bacteria to plants to animals that needs oxygen to survive produces and uses its own supply of glutathione in every one of its cells. It is absolutely essential for life.
Glutathione is a tripeptide (small protein) composed of the three amino acids glutamate, cysteine and glycine. It is made in each of the cells in your body by two sequential enzyme catalysed reactions. The first joins glutamate and cysteine to produce Glyteine (gamma glutamylcysteine) and the second adds the glycine to form glutathione. This process […]
Glyteine (gamma glutamylcysteine) is the immediate precursor to glutathione. During ageing and in many chronic conditions, the affected cells lose the capacity to make enough gamma-glutamylcysteine to maintain sufficient levels of glutathione to fight off oxidative stress. Gamma-glutamylcysteine is synthesized by glutamate cysteine ligase (GCL) and it is unhealthy and permanent changes to this enzyme […]
Glyteine is a proprietary form of the dipeptide (small protein) gamma-glutamylcysteine, which is the immediate precursor to the tripeptide, glutathione. Glutathione is synthesized in every cell of all oxygen using living organisms from bacteria, through to plants and animals. This synthesis is facilitated by two enzymes (biological catalysts). The first enzyme, glutamate cysteine ligase (GCL) […]