As our lifespan increases, we become more susceptible to persistent health issues. Especially those brought on by oxidative stress, like neurodegenerative diseases  which insidiously affect our brain and cognition.
A compromised glutathione system in the brain has a strong correlation with oxidative stress and has been shown to be implicated in neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, progressive supranuclear palsy, Huntington’s disease and multiple sclerosis [3-5].
It is now possible to determine the concentration of glutathione in living human brains using magnetic resonance spectroscopy (MRS), with multiple MRS studies showing depleted brain glutathione levels in all the major neurodegenerative diseases [6-9].
Strategies to increase neuronal or brain glutathione as a potential treatment have been proposed by many researchers. However, none of the therapeutic candidates have been successful so far [10-12], with the major impediment for most being a failure to cross the blood-brain barrier. As yet, there is no direct evidence to suggest that orally administered Glyteine can reach the human brain . An MRS human clinical study is underway to determine if oral supplementation with Glyteine can increase brain glutathione levels.